Table of ContentsFeaturesMULTISPECTRAL IMAGING/PATHOLOGY: Quantitating multiple signaling pathway proteins in intact tissueA recent study has demonstrated, for the first time, that it's possible to detect-and automatically measure-key activity indicators of cancer cell signal transduction pathways in intact tissue.
OPTICAL COHERENCE TOMOGRAPHY/CARDIOLOGY: Totally tubular: Cardiovascular OCT goes prime timeRecent FDA approval of LightLab's intravascular imaging system launched OCT's second clinical market.
FLUORESCENCE: Taking life by STORMStochastic optical reconstruction microscopy (STORM) enables generation of 2D and 3D multicolor imaging of tissues and cells with near molecular-scale resolution. DepartmentsBioOptics BreakthroughsNano-optics advancement detects cells, viruses, moleculesResearchers at the University of Iceland, Harvard University, the University of Cologne and the Fraunhofer Institute Jena have demonstrated net optical amplification in a plasmonic waveguide.
Fluorescent labeling technique overcomes setbacks of GFPA green fluorescent protein known simply as GFP has revolutionized cell biology.
3D test promotes early skin cancer detectionScientists from the Bristol Institute of Technology, University of the West of England, Bristol have developed a 3D test for malignant melanoma that can identify problems not easily spotted in a standard, 2D view of the pattern on the skin.
Biosensing gets a boost from optoelectric approachA method that uses a combination of light and electric fields to position droplets promises to enable medical diagnostics. Ordinarily, particles such as bacteria, viruses and DNA contained within droplets are detected when they randomly fall on the surface of a sensor.
News & ViewsBIOPHOTONICS RESEARCH: Proposed federal funding plan would augment existing optionsRecent reauthorization of the America COMPETES Act may do more than keep the National Science Foundation (NSF), the Department of Energy, and the National Institute of Standards and Technology on track to double their budgets by 2017.
SPECTROSCOPY/MEDICAL DIAGNOSTICS: Optical device promises point-of-care blood analysis at 10× cost reductionAn investment of $1.3 million from the Federal Economic Development Agency for Southern Ontario is helping P&P Optica Inc. (Kitchener, Canada) develop "near-instantaneous" blood analysis instruments for the point-of-care medical market.
NANOPOSITIONING: Piezo motors and actuators drive bio-optics precisionPrecision and accuracy are at the heart of biomedical instrumentation, including imaging and treatment tools—and the motors these instruments incorporate have much to do with their performance.
SPECTROSCOPY/PATHOLOGY: Amyloid fibril discovery promises neuropathology insightAdvanced laser spectroscopy has enabled the discovery of a new phenomenon that has implications for the treatment of neurodegenerative disease
OPTICAL COHERENCE TOMOGRAPHY: Inexpensive GPU key to broadly accessible real-time 3D FD-OCTSuper-high speed Fourier-domain optical coherence tomography (FD-OCT) sure would be useful for such clinical applications as surgery: Real-time 3D video would give surgeons a better understanding of tissue and provide instrument guidance during operations.
SPECTROSCOPY/LASER-TISSUE INTERACTION: NIR spectroscopy device promising for diabetic wound healingA new device, based on diffuse near-infrared (NIR) spectroscopy, promises to change chronic wound management.
Product ShowcaseComponents & Systems ProductsThe SPECTRA light engine provides seven discrete solid-state outputs that span the complete visible spectrum from 380 to 680 nm, making it a true arc lamp replacement.
End ResultPulsed laser/LED treatment gets eagle flying againWhen a four-month-old bald eagle was taken to the Wildlife Rehabilitation Center at the Conservancy of Southwest Florida (Naples, FL) in early May, it was unable to fly.
ColumnsEditor's ColumnFeld's biospectroscopy legacyIn a recent webcast, Harvard chemistry professor Sunney Xie (http://bit.ly/aXyGAi) explored label-free imaging of living cells and organisms based on molecular spectroscopy.
Inside InstrumentationShining near-infrared light on lifeThe light that we see ranges from purples to reds, or wavelengths of 400-700 nm.
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